The impacts of ectopic fats in muscle, liver, and abdominal tissues on the metabolism related to glucose and insulin

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293140
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Fujiyoshi Akira 滋賀医科大学, 医学部, 准教授 (10567077)
• Co-Investigator(Kenkyū-buntansha): 東 宏一郎 慶應義塾大学, 医学部(信濃町), 講師 (60317104) ; 門脇 紗也佳 滋賀医科大学, 医学部, その他 (60510344) ; 上島 弘嗣 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483) ; 三浦 克之 滋賀医科大学, 医学部, 教授 (90257452) ; 久松 隆史 滋賀医科大学, 医学部, 客員准教授 (60710449)
• Co-Investigator(Renkei-kenkyūsha): MURATA Kiyoshi 滋賀医科大学, 医学部, 教授 (20127038) ; MAEGAWA Hiroshi 滋賀医科大学, 医学部, 教授 (00209363)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 異所性脂肪 / 筋肉 / 地域一般住民

Outline of Final Research Achievements

As planned, we have finished reading the total of approximately 2,400 images, and cleaned the data of it. Also, we have obtained multiple measures related to glucose-insulin metabolism. Using those data, we have obtained preliminary results as follows: In a population-based samples of men aged 40years or older, 1) older individuals had lower body mass index, smaller muscle areas, but larger fat-muscle areas; 2) age and weight were the major predictors of muscle areas/mass; 3) abdominal visceral adipose tissue was most strongly correlated to glucose, triglycerides and inflammation as compared to other factors we studied.

Free Research Field

疫学、予防医学