Comprehensive analysis of inflammatory bowel disease using by genome-wid genetic and epigenetic association studies

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293180
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nihon University (2016-2017); Institute of Physical and Chemical Research (2014-2015)
• Principal Investigator: YAMAZAKI Keiko 日本大学, 医学部, 助教 (50415329)
• Co-Investigator(Kenkyū-buntansha): 鈴木 康夫 東邦大学, 医学部, 教授 (40261911) ; 江崎 幹宏 九州大学, 大学病院, 講師 (50335957) ; 梅野 淳嗣 九州大学, 大学病院, 助教 (70621704) ; LOW SIEWKEE 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 (40634720)
• Research Collaborator: MOTOYA Satoshi ; FUYUNO Yuta
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 炎症性腸疾患 / 全ゲノム関連解析 / 薬剤応答性

Outline of Final Research Achievements

The aim of this project is to clarify the pathogenesis of inflammatory bowel disease (IBD) using by analysis of genome-wide genetic and epigenetic association. Since it is difficult to design using whole-genome epigenetic analysis for multifactorial disease except cancer, we focus the response of anti TNF-α monoclonal antibody in IBD. We have rescrueted patients with IBD who were treated with anti TNF-α antibody for the first time and examined methylation assays including whole-genome bisulfite sequncing.
Furthermore, we collaborated with the International IBD Genetics Consortium and conducted transancestry association study of IBD. Out trans-ethinic genome-wide association study clarified that the direction and magnitude of effect are consistent in European and non-European cohorts in spite of the genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency or effect size.

Free Research Field

疾患遺伝学