2016 Fiscal Year Final Research Report
Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism
| Project/Area Number |
26293187
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Shinshu University (2016)
Kyoto University (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木下 秀之 京都大学, 医学(系)研究科(研究院), 准教授 (30467477)
中川 靖章 京都大学, 医学(系)研究科(研究院), 助教 (70452357)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKANO makoto 久留米大学, 医学部, 教授 (30236252)
ARAI yuji 国立研究開発法人国立循環器病研究センター, 分子生物学部, 室長 (30202724)
MORI yasuo 京都大学, 工学研究科, 教授 (80212265)
NISHIDA motohiro 大学共同利用機関法人自然科学研究機構, 岡崎統合バイオサイエンスセンター, 教授 (90342641)
YAMADA mitsuhiko 信州大学, 学術研究院医学系, 教授 (10263237)
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| Research Collaborator |
Neubig Richard ミシガン州立大学, 教授
Olson Eric N. テキサス大学, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 分子心臓学 / 心不全 / 遺伝子 |
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| Outline of Final Research Achievements |
We examined the transcriptional and epigenomic regulation of cardiac gene expression involved in maintaining cardiac function and metabolism. We revealed the role of NRSF-HDAC complex in maintaining cardiac function by using NRSF gene manipulated mice. In addition, we addressed the possible importance of MRTF-A, a rho-dependent co-activator of SRF, and TRPC3/6 as novel therapeutic targets for the treatment of heart failure.
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| Free Research Field |
循環器内科学
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