Comprehensive strategy of heart failure, cardiac hypertrophy and lethal arrhythmia via stabilizing the stricture of ryanodine receptor

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293189
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Yamaguchi University
• Principal Investigator: YANO Masafumi 山口大学, 医学(系)研究科(研究院), 教授 (90294628)
• Co-Investigator(Kenkyū-buntansha): 小田 哲郎 山口大学, 医学部附属病院, 助教 (40569290) ; 小林 茂樹 山口大学, 医学部附属病院, 講師 (90397993)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: リアノジン受容体 / Caハンドリング / カルモジュリン

Outline of Final Research Achievements

In this study, we succeeded in stabilizing the structure of RyR by controlling the affinity of RyR-bound CaM, and further stabilizing the structure of RyR improves Ca handling of the defective myocardium, effective treatment of heart failure It turned out to be a law. We also clarified that stabilization of RyR structure can also suppress cardiac hypertrophy by preventing divergence of CaM from RyR. Finally, it was clarified that it is possible to treat genetic lethal arrhythmia and fatal arrhythmia in experimental heart failure model by structural stabilization of RyR.

Free Research Field

循環器内科学