2017 Fiscal Year Final Research Report
Possibility as diagnostic agent and the role in vivo of Big angiotensin-25
| Project/Area Number |
26293191
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鶴田 敏博 宮崎大学, 医学部, 准教授 (10389570)
加藤 丈司 宮崎大学, フロンティア科学実験総合センター, 教授 (20274780)
桑迫 健二 宮崎大学, フロンティア科学実験総合センター, 准教授 (20381098)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | Bang-25 / アンジオテンシン / バイオマーカー / 糖鎖ペプチド / 生合成酵素 / 抗Bang-25抗体 |
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| Outline of Final Research Achievements |
We developed assay of Big angiotensin-25 (Bang-25) and measured urinary Bang-25. Human urinary Bang-25 had negative correlation with estimated glomerulus filtration rate, but did not correlate with the urine protein. Furthermore, when compared with diabetes mellitus patients, the urinary Bang-25 was higher than healthy volunteer. These results show that urinary Bang-25 is associated with kidney injury and diabetes mellitus.
Next, we analyzed the 14th glycosyl chain of Angiotensinogen (Aogen). One of the glycosyl chains of Aogen is same as Bang-25. The possibility that produce of angiotensin-related peptide including Bang-25 or Ang I was changed by the difference of the glycosyl chain of Aogen.
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| Free Research Field |
循環器内科学
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