Roles of metabolic regulation in B cell fate determination

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293229
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Ikawa Tomokatsu 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (60450392)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: B細胞 / 運命決定 / 代謝 / 造血幹細胞 / 分化

Outline of Final Research Achievements

All hematpoietic / immune cells including B cells are generated from hematopoietic stem cells(HSCs). HSCs gradually specify their differentiation potential to finally commit to the B cell lineage. Although transcription factors (TFs) are shown to be essential for the cell fate decision, the roles of the TFs in regulating cellular metabolisms remain to be determined. We have recently established a culture system to examine the molecular mechanisms of B cell fate determination. Using this sytem, we demonstrated that the insulin signals are important for early B cell differentiation.

Free Research Field

免疫学、血液学