Roles of epigenetic mechanism on cerebral cortical histogenesis in congenital malformation syndrome

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293248
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Keio University
• Principal Investigator: TAKAHASHI TAKAO 慶應義塾大学, 医学部, 教授 (80171495)
• Co-Investigator(Kenkyū-buntansha): 小崎 健次郎 慶應義塾大学, 医学部, 教授 (30234743) ; 三橋 隆行 慶應義塾大学, 医学部, 講師 (80338110)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 神経発生 / 大脳皮質 / エピゲノム / 細胞周期

Outline of Final Research Achievements

Epigenetic mechanisms that are governed by histone acetylation are considered to have a critical role in neuronal differentiation. In this analysis, we have attempted to generate transgenic mice that would be capable of decreasing an expression level of CBP protein, a causative protein for Rubinstein-Taybi syndrome. In addition, we have analyzed effects of in utero exposure of valproate, a putative candidate for treating Rubinstein-Taybi syndrome, on cerebral cortical histogenesis. Valproate exposure in utero increased the thickness of cerebral cortex by affecting the cell cycle kinetics of neuronal progenitor cells.

Free Research Field

医歯薬学