The genotype, the phenotype and the end-phenotype measured by MEG in autism spectrum disorder.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293262
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: Kikuchi Mitsuru 金沢大学, 子どものこころの発達研究センター, 教授 (00377384)
• Co-Investigator(Kenkyū-buntansha): 横山 茂 金沢大学, 子どものこころの発達研究センター, 教授 (00210633) ; 真田 茂 金沢大学, 保健学系, 教授 (50020029) ; 吉村 優子 金沢大学, 子どものこころの発達研究センター, 助教 (70597070)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 自閉スペクトラム症 / 脳磁図 / 幼児 / 遺伝子多型 / MET遺伝子 / 社会性 / ワーキングメモリ / 言語発達

Outline of Final Research Achievements

The symptom of ASD was evaluated using the behavioral and neurophysiological methods. We researched the effect of the genotype (which was thought to be risk type for ASD) on phenotype measured by behavioral data and end-phenotype measured by MEG. Young children with ASD (N=71: including the repeated subjects) and typically developing children (N=102: including the repeated subjects) participated. At the present moment, single nucleotide polymorphism of rs1858830 in a MET gene have identified in 33 children with ASD and 30 TD children. We defined CC and a CG genotype (which include risk type genetic polymorphism C) as CC_CG group, and we compared some phenotype and end-phenotype between CC_CG and GG groups. As the result, in the ASD group including genetic polymorphism C, developmental delay was observed in working memory task. On the other hand, TD group was affected by the risk gene more about the latency of auditory evoked field measured by MEG.

Free Research Field

児童精神医学