In vivo imaging study for the timing of neurogenesis and neuroinflammation altered in Alzheimer's disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293263
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Yasuomi Ouchi 浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978)
• Co-Investigator(Kenkyū-buntansha): 間賀田 泰寛 浜松医科大学, 光尖端医学教育研究センター, 教授 (20209399) ; 植木 孝俊 名古屋市立大学, 医学(系)研究科(研究院), 教授 (60317328) ; 寺田 達弘 浜松医科大学, 光尖端医学教育研究センター, 特任研究員 (80550178)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アルツハイマー病 / 神経新生 / ミクログリア活性

Outline of Final Research Achievements

We examined molecules that relate to microglial activation and investigated a linkage between neurogenesis and neuroinflammation using AD-like animal models (SAMP8 mice and naturally-developed demented macaque confirmed by [11C]PIB for amyloid pathology) by developing methods with which we were able to quantify the amount of neurogenesis and determine the types of microglial activation: protective or inflammatory.
With the SAMP8 mice, a combination of Nestin promoter LAT4 system and [18F]dFMT enabled to illustrate the neurogenesis but the signal was small and ex vivo postmortem brain imaging was found to be necessary. Using a CB2R ligand permitted to depict microglial activation, but we found a more sensitive probe and method system necessary for examining these two phenomena in vivo in a living single animal.

Free Research Field

神経画像学