Molecular imaging of brain disease model mice by MRI and EPR imaging

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293280
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Sapporo Medical University
• Principal Investigator: FUJII HIROTADA 札幌医科大学, 医療人育成センター, 教授 (70209013)
• Co-Investigator(Renkei-kenkyūsha): SHIMOHAMA Syun 札幌医科大学, 医学部, 教授 (60235687) ; SATO Shingo 山形大学, 理工学研究科, 教授 (30215793) ; AKABA Hideo 大阪大学, 基礎工学研究科, 准教授 (00552077)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脳疾患 / 分子イメージング / MRI / EPR / 酸化ストレス

Outline of Final Research Achievements

Reactive oxygen species (ROS) and free radicals are continuously generated in brains. An excess of ROS has been reported to play an important role in neurodegenerative diseases. In the present stud, a new magnetic resonance-based imaging method using electron paramagnetic resonance and MRI was develop in order to visualize redox status in neurodegenerative disease model animals. Three animal models such as Alzheimer disease and epilepsy, was employed. Our new molecular imaging method clearly visualized a change in redox status of mouse brain, and these results can be used for medicine.

Free Research Field

磁気共鳴イメージング