Development of imaging agents for feeding function as a diagnostic tool and evaluation of drug therapy for obesity

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293283
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: KAWAMURA KAZUNORI 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, チームリーダー(定常) (50401766)
• Co-Investigator(Kenkyū-buntansha): 謝 琳 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, 研究員(任常) (30623558) ; 藤永 雅之 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, 主任研究員(定常) (70623726) ; 張 明栄 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, 部長(定常) (80443076) ; 山崎 友照 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 標識薬剤開発部, 研究員(任常) (80627563)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 核医学 / PET / 分子イメージング / 摂食 / 肥満 / イミダゾリン受容体 / グレリン受容体

Outline of Final Research Achievements

To treat obesity by drug therapy targeted a feeding center, several drugs have been developed. In this study, we developed the positron emission tomography (PET) probe for high affinity and selectivity imidazoline-I2 receptor (I2R), which is named ultrahigh specific activity [11C]BU99008. Also, we demonstrated to image and quantity a small change in a feeding center by obesity, and the relationship between I2R and obesity using [11C]BU99008-PET study in rats. Thus, we concluded that [11C]BU99008-PET study is helpful for the diagnostic tool or evaluation of drug therapy for obesity. Furthermore, we achieved to apply for clinical application using [11C]BU99008-PET study.

Free Research Field

放射性薬品科学