Lung repair by inhalation therapy during ex-vivo lung perfusion for lung transplantation from donation after circulatory death

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293315
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Kyoto University
• Principal Investigator: Date Hiroshi 京都大学, 医学(系)研究科(研究院), 教授 (60252962)
• Co-Investigator(Kenkyū-buntansha): 陳 豊史 京都大学, 医学(系)研究科(研究院), 講師 (00452334) ; 小池 薫 京都大学, 医学(系)研究科(研究院), 教授 (10267164) ; 佐藤 寿彦 京都大学, 医学(系)研究科(研究院), 准教授 (40388822) ; 青山 晃博 京都大学, 医学(系)研究科(研究院), 助教 (60379047) ; 佐藤 雅昭 京都大学, 医学(系)研究科(研究院), 助教 (00623109) ; 山田 徹 京都大学, 医学(系)研究科(研究院), 助教 (90534347)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: lung transplantation / ex-vivo lung perfusion / inhalation therapy / circulatory death / surfactant

Outline of Final Research Achievements

Severe shortage of brain dead donor is unsolved problem in Japan. Lung transplantation from donation after circulatory arrest (DCD) may increase the donor pool. Ex-vivo lung perfusion (EVLP) is a potential modality to repair lung injury caused by warm ischemic change. Beagle lungs were harvested 150 minutes after circulatory arrest and perfused by EVLP for 4 hours and these lungs were implanted to the recipient animal. Inhalation with β2 adrenoreceptor agonist and surfactant during EVLP significantly improved lung function after transplantation. These results suggested that lung transplantation for DCD donor is possible.

Free Research Field

呼吸器外科