Development and practical application of a short-term replacement bone prosthesis to control infection

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293339
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: Tanaka Masato 岡山大学, 医歯(薬)学総合研究科, 准教授 (20379754)
• Co-Investigator(Kenkyū-buntansha): 尾崎 敏文 岡山大学, 医歯(薬)学総合研究科, 教授 (40294459) ; 沖原 巧 岡山大学, 自然科学研究科, 講師 (70243491) ; 渡邉 典行 岡山大学, 大学病院, 医員 (80708107)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: リン酸化プルラン / 骨髄炎

Outline of Final Research Achievements

We investigated the availability of a new bone prosthetic material, which contains an antibacterial agent using phosphorylated-pullulan. Examination was done to measure the sustained release of the antibacterial agent from the bone prosthetic material. The new bone material had greater sustained release abilities compared to conventional bone material. Using an osteomyelitis mouse model, prepared by injecting S. aureus into the mouse bone marrow, we found a significant strong antimicrobial effect compared to conventional bone substitute material. These results suggest that phosphorylated-pullulan represents a drug delivery system for bone tissue, which is effective for preventing infections using an antibacterial agent.

Free Research Field

整形外科学