Common genetic mechanisms underlying vulnerability to pain and sensitivity to analgesics among different populations of patients with pain.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293347
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: IKEDA Kazutaka 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)
• Co-Investigator(Kenkyū-buntansha): 西澤 大輔 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (80450584) ; 福田 謙一 東京歯科大学, 歯学部, 教授 (80228907) ; 笠井 慎也 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (20399471)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 薬物反応性 / ゲノム / 薬理学 / 脳神経疾患 / 医療・福祉 / 国際研究者交流

Outline of Final Research Achievements

Huge individual differences in vulnerability to pain and in responsibility to its therapy hamper effective therapy for pain. In the present study, we analyzed genetic polymorphism data and clinical data and found polymorphisms associated with responsibility to analgesics. Using these polymorphisms and demographic data of patients, we constructed a formula for predicting adequate amount of analgesic for postoperative pain in individual patients. We further constructed formulas for perioperative pain and verified them in other populations of patients with perioperative pain. Personalized pain treatment has begun using prediction formulas, and improvements in personalized pain treatment are expected as scientific knowledge further expands in the future.

Free Research Field

精神神経薬理学