Investigation of the anti inflammatory and antifibrotic function of regulatory T cells to establish the immune cell therapy in keloid

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293379
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Hokkaido University
• Principal Investigator: MURAO Naoki 北海道大学, 大学病院, 助教 (90706558)
• Co-Investigator(Kenkyū-buntansha): 舟山 恵美 北海道大学, 医学(系)研究科(研究院), 講師 (10533630) ; 山本 有平 北海道大学, 医学(系)研究科(研究院), 教授 (70271674) ; 小山 明彦 北海道大学, 大学病院, 講師 (70374486) ; 七戸 龍司 北海道大学, 大学病院, 医員 (30640346) ; 古川 洋志 北海道大学, 医学(系)研究科(研究院), 准教授 (00399924) ; 林 利彦 北海道大学, 歯学研究科(研究院), 准教授 (00432146) ; 齋藤 典子 北海道大学, 医学(系)研究科(研究院), 客員研究員 (80374487) ; 関堂 充 筑波大学, 医学医療系, 教授 (40372255)
• Co-Investigator(Renkei-kenkyūsha): SEINO Kenichiro 北海道大学, 遺伝子病制御研究所, 教授 (20312845)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ケロイド

Outline of Final Research Achievements

Keloid is an inflammatory and fibrotic disease. CD4+ T cells have been shown to play an important role in regulating inflammation and fibrosis. CD4+ T cells, especially regulatory T cells, suppress the inflammatory response and the expression of inflammatory cytokines via secreting an anti inflammatory cytokine IL-10. Nevertheless, little is known about the role of CD4+ T cells in the pathogenesis of keloid. We therefore investigated the interaction between CD4+ T cells and keloid fibroblasts using a coculture system. Our data suggested that IL-10 secreted from CD4+ T cells attenuate IL-6 production in keloid fibroblasts. Strategies to activate CD4+ T cells secreting IL-10 in keloids might represent a novel approach for the treatment of keloids.

Free Research Field

ケロイド