Development of hydrogels with the ability to release antimicrobials for long term and their application to various resin-based materials

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293409
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: Imazato Satoshi 大阪大学, 歯学研究科(研究院), 教授 (80243244)
• Co-Investigator(Kenkyū-buntansha): 佐々木 淳一 大阪大学, 歯学研究科(研究院), 助教 (50530490) ; 高橋 雄介 大阪大学, 歯学部附属病院, 講師 (60397693) ; 岩崎 泰彦 関西大学, 工学部, 教授 (90280990)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 歯学 / 歯科材料 / レジン / 抗菌性 / ドラッグデリバリー / 抗菌剤

Outline of Final Research Achievements

In this study, non-biodegradable hydrogels composed of HEMA and a cross-linking monomer TMPT, to be used as a reservoir of antimicrobials, were fabricated. These novel hydrogels were found to be able to work as a carrier of cetylpyridinium chloride (CPC), enabling long-term release of CPC in a wet environment. By incorporation of CPC-loaded polyHEMA/TMPT hydrogel particles, it is possible to provide MMA-based resins or HEMA-based endodontic sealers with long-lasting antibacterial effects, keeping their physical properties in clinically acceptable level.Thus, we successfully developed a sustained antimicrobial-release system useful for achievement of reconstructive materials which exhibit long-lasting antibacterial effects.

Free Research Field

歯科生体材料学