2017 Fiscal Year Final Research Report
New strategy targeted at innate immunity for the pathologic clarification of new disease concept "IgG4-related disease"
| Project/Area Number |
26293430
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 誠司 九州大学, 歯学研究院, 教授 (60189040)
中島 衡 福岡大学, 医学部, 教授 (70188960)
坪井 洋人 筑波大学, 医学医療系, 講師 (80580505)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | IgG4関連疾患 / 自然免疫 / Toll様受容体 |
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| Outline of Final Research Achievements |
IgG4-related disease (IgG4-RD) is a unique inflammatory disorder. In addition, recent studies have also implicated the Toll-like receptor (TLR) pathway. Here, we examined the expression of TLRs in salivary glands (SGs) from patients with IgG4-RD. In patients with IgG4-RD, TLR7 was overexpressed compared with the other groups. Immunohistochemical analysis confirmed strong infiltration of TLR7-positive cells in the SGs of patients with IgG4-RD. Double immunohistochemical staining showed that TLR7 expression co-localized with CD163+ M2 macrophages. In huTlr7 Tg mice, the focus and fibrosis score in SMGs, pancreas, and lungs were significantly higher than those in wild-type mice. Moreover, the concentration of serum IgG in huTlr7 Tg mice was significantly higher than that in wild-type mice and distinctly increased upon stimulation with TLR7 agonist. Thus, huTlr7 Tg mice could lead to the establishment of a mouse model of IgG4-RD.
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| Free Research Field |
臨床免疫学
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