Real-time monitoring of the oxidative stress in brain induced by occlusal disharmony

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293441
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: Morita Manabu 岡山大学, 医歯(薬)学総合研究科, 教授 (40157904)
• Co-Investigator(Kenkyū-buntansha): 江國 大輔 岡山大学, 大学病院, 講師 (70346443) ; 友藤 孝明 岡山大学, 医歯(薬)学総合研究科, 准教授 (80335629) ; 東 哲司 岡山大学, 医歯(薬)学総合研究科, 助教 (80432649)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 酸化ストレス / 咬合異常 / 抗酸化物質

Outline of Final Research Achievements

We succeeded to visualize oxidative stress in brain after inducing occlusal disharmony in a Keap1-dependent oxidative stress detector-luciferase (OKD-LUC) mouse. The stress level was greater in mice with bilateral occlusal disharmony than those with unilateral. The intake of hydrogen-rich water (HW) did not reduce the heme oxygenase-1 (HO-1) gene expression, which is an oxidative stress inhibitor. The visualized oxidative stress level was lower in WH-intake, however the effect was transient.

Free Research Field

予防歯科学