Ecological and human risk assessment of vector control pesticides

2016 Fiscal Year Annual Research Report

• Project/Area Number: 26304043
• Research Institution: Hokkaido University
• Principal Investigator: 池中 良徳 北海道大学, (連合)獣医学研究科, 准教授 (40543509)
• Co-Investigator(Kenkyū-buntansha): 石塚 真由美 北海道大学, (連合)獣医学研究科, 教授 (50332474) ; 水川 葉月 北海道大学, (連合)獣医学研究科, 助教 (60612661) ; 中山 翔太 北海道大学, (連合)獣医学研究科, 助教 (90647629)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ベクターコントロール / DDT / 屋内限定散布(IRS) / 野生動物 / 化学物質感受性評価 / 種差 / 南アフリカ共和国

Outline of Annual Research Achievements

アフリカ地域において、感染症制圧は依然として緊急性の高い課題であり、我が国からも精力的にその研究・支援が行われている。2006年、WHOとUSADIは病原体媒介生物のコントロールのため、有機塩素系農薬であるDDTの屋内限定散布（IRS）を推奨した。即ち、現在のVector Controlにおいて、DDTに代替えする薬剤は限られており、その年間散布量は、アジア・アフリカ地域を中心に5000トンに達していると報告されている。その結果、マラリアによる死亡率は2000年に比べ世界で25％、アフリカでは33％減少し、一定のbenefitが得られた事が報告された。その一方、IRSは屋内に薬剤を直接散布するため、そのヒト健康影響が懸念されているが、その影響は不明な点が多い。そこで、本研究では、「Vector Control地域におけるDDTやピレスロイドの中・長期使用時の人健康および生態系へのriskを予測する」ことを目的とした。
2016年度は、2015年度に引き続きマラリアコントロール地域である南アフリカ共和国クワズルナタール・ンドゥモで特に齧歯類とニワトリに注目して試料採集を継続した。
特にニワトリや卵を食品として摂取したときのヒトリスク評価をEPAの方法に準拠して実施したところ、食べ続ける事によって1％以上という極めて高い発癌リスクが生じる事が計算できた。次に、ニワトリ自身への毒性影響を明らかにするためにマイクロアレイを実施した。72の遺伝子発現が有意に抑制されている事が明らかになり、ニワトリに対しても一定の影響を与えている事が示唆された。

Research Progress Status

28年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

28年度が最終年度であるため、記入しない。

Causes of Carryover

28年度が最終年度であるため、記入しない。

Expenditure Plan for Carryover Budget

28年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] North-West University/Johannesburg University(南アフリカ共和国)
  • Country Name: 南アフリカ共和国
  • Counterpart Institution: North-West University/Johannesburg University
• [Int'l Joint Research] Gondar University(エチオピア連邦民主共和国)
  • Country Name: エチオピア連邦民主共和国
  • Counterpart Institution: Gondar University
• [Int'l Joint Research] Kasetsart University(タイ王国)
  • Country Name: タイ王国
  • Counterpart Institution: Kasetsart University
• [Int'l Joint Research] Zagazig University(エジプト)
  • Country Name: エジプト
  • Counterpart Institution: Zagazig University
• [Journal Article] "非実験動物における化学物質代謝能の特徴と種差 Characterization of species differences of xenobiotic metabolism in non-experimental animals " (2017)
  • Author(s): 水川葉月、池中良徳、筧麻友、中山翔太、石塚真由美
  • Journal Title: YAKUGAKU ZASSHI Volume: 137 Pages: 257-263
  • DOI: 10.1248/yakushi.16-00230-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Contamination status and accumulation characteristics of heavy metals and arsenic in five seabird species from the central Bering Sea (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Yared Beyene Yohannes, Yutaka Watanuki, Masaaki Fukuwaka, and Mayumi Ishizuka
  • Journal Title: JVMS Volume: in press Pages: in press
  • DOI: doi: 10.1292/jvms.16-0441.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Organochlorine pesticide contamination of foods in Africa: incidence and public health significance (2017)
  • Author(s): Lesa A Thompson, Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta M M Nakayama, Hazuki Mizukawa and Mayumi Ishizuka
  • Journal Title: JVMS Volume: in press Pages: in press
  • DOI: 10.1292/jvms.16-0214
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Monitoring lead (Pb) pollution and identifying Pb pollution sources in Japan using stable Pb isotope analysis with kidney of wild rats. (2017)
  • Author(s): Nakata H*, Nakayama SMM*, Oroszlany B, Ikenaka Y, Mizukawa H, Tanaka K, Harunari T, Tanikawa T, Darwish WS, Yohannes YB, Saengtienchai A, Ishizuka M (* Equal contribution).
  • Journal Title: Int. J. Environ. Res. Public Health Volume: in press Pages: in press
  • DOI: 10.3390/ijerph14010056
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Trace Element Contamination in Tissues of Four Bird Species from the Rift Valley Region, Ethiopia. (2017)
  • Author(s): Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
  • Journal Title: BECT Volume: 98 Pages: 172-177
  • DOI: 10.1007/s00128-016-2011-4
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] DDTs and other organochlorine pesticides in tissues of four bird species from the Rift Valley region, Ethiopia. (2017)
  • Author(s): Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
  • Journal Title: Sci. Total. Environ. Volume: 574 Pages: 1389-1395
  • DOI: 10.1016/j.scitotenv.2016.08.056.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis. (2016)
  • Author(s): Takeda K*, Ikenaka Y*, Tanikawa T, Tanaka KD, Nakayama SMM, Mizukawa H, Ishizuka M (*Equal contribution).
  • Journal Title: Pestic Biochem Physiol. Volume: 134 Pages: 1-7
  • DOI: 10.1016/j.pestbp.2016.04.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The African hedgehog (Atelerix albiventris): low phase I and phase II metabolism activities. (2016)
  • Author(s): Saengtienchai A, Ikenaka Y, Bortey-Sam N, Jermnark U, Mizukawa H, Kawai YK, Nakayama SMM, Ishizuka M.
  • Journal Title: Comp Biochem Physiol C Pharmacol Toxicol. Volume: 190 Pages: 38-47
  • DOI: 10.1016/j.cbpc.2016.08.005.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Excretion of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in cattle urine in Ghana. (2016)
  • Author(s): Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Marfo J, Saengtienchai A, Mizukawa H, Ishizuka, M.
  • Journal Title: Environmental Pollution Volume: 218 Pages: 331-337
  • DOI: 10.1016/j.envpol.2016.07.008
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Heavy metals and metalloid accumulation in livers and kidneys of wild rats around gold-mining communities in Tarkwa, Ghana. (2016)
  • Author(s): Bortey-Sam N*, Nakayama SMM*, Ikenaka Y, Akoto O, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution).
  • Journal Title: Journal of Environmental Chemistry and Ecotoxicology, Volume: 8 Pages: 58-68
  • DOI: 10.5897/JECE2016.0374
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Characterization of Equine Cytochrome P450: Role of CYP3A in the Metabolism of Diazepam. (2016)
  • Author(s): Nakayama SMM, Ikenaka Y, Hayami A, Mizukawa H, Darwish WS, Watanabe KP, Kawai YK, Ishizuka M.
  • Journal Title: Journal of Veterinary Pharmacology and Therapeutics. Volume: 39 Pages: 478-87
  • DOI: 10.1111/jvp.12303.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Feather mercury concentration in streaked shearwaters wintering in separate areas of Southeast Asia. (2016)
  • Author(s): Watanuki Y, Yamashita A, Ishizuka M, Ikenaka Y, Nakayama SMM, Ishii C, Yamamoto T, Ito M, Kuwae T, Trathan PN.
  • Journal Title: Mar Ecol Prog Ser. Volume: 546 Pages: 263-269
  • DOI: 10.3354/meps11669
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Constitutive Effects of Lead on Aryl Hydrocarbon Receptor Gene Battery and Protection by β-carotene and Ascorbic Acid in Human HepG2 Cells. (2016)
  • Author(s): Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
  • Journal Title: J. Food. Sci. Volume: 81 Pages: T275-81
  • DOI: 10.1111/1750-3841.13162.
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Bioaccumulation and human health risk assessment of DDT and other organochlorine pesticides in an apex aquatic predator from a premier conservation area. (2016)
  • Author(s): Gerber R, Smit NJ, Van Vuren JH, Nakayama SMM, Yohannes YB, Ikenaka Y, Ishizuka M, Wepener V.
  • Journal Title: Sci. Total. Environ. Volume: 550 Pages: 522-533
  • DOI: 10.1016/j.scitotenv.2016.01.129
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Strain differences in cytochrome P450 mRNA and protein expression, and enzymatic activity among Sprague Dawley, Wistar, Brown Norway and Dark Agouti rats. (2016)
  • Author(s): Nishiyama Y, Nakayama SMM, Watanabe KP, Kawai YK, Ohno M, Ikenaka Y, Ishizuka M.
  • Journal Title: JVMS Volume: 78 Pages: 675-80
  • DOI: 10.1292/jvms.15-0299.
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Organohalogen compounds in pet dog and cat: Do pets biotransform natural brominated products in food to harmful hydroxlated substances? (2016)
  • Author(s): Mizukawa H, Nomiyama K, Nakatsu S, Iwata H, Yoo J, Kubota A, Yamamoto M, Ishizuka M, Ikenaka Y, Nakayama S, Kunisue T, Tanabe S.
  • Journal Title: Environ. Sci. Technol. Volume: 50 Pages: 442-52
  • DOI: 10.1021/acs.est.5b04216
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reliability of stable Pb isotopes to identify Pb sources and verifying biological fractionation of Pb isotopes in goats and chickens. (2016)
  • Author(s): Nakata H*, Nakayama SMM*, Yabe J, Liazambi A, Mizukawa H, Darwish WS, Ikenaka Y, Ishizuka M (* Equal contribution).
  • Journal Title: Environ Pollut. Volume: 208 Pages: 395-403
  • DOI: 10.1016/j.envpol.2015.10.006
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Distribution and health risk assessment of organochlorine pesticides (OCP) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCP in tongue. (2016)
  • Author(s): Mahmoud AFA, Ikenaka Y, Yohannes YB, Darwish WS, Eldaly EA, Morshdy AE, Nakayama SMM, Mizukawa H, Ishizuka M.
  • Journal Title: Chemosphere Volume: 144 Pages: 1365-71
  • DOI: 10.1016/j.chemosphere.2015.10.016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 代謝酵素の動物種差 (2017)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 日本薬学会第137年会シンポジウム
  • Place of Presentation: 仙台国際センター、仙台市
  • Year and Date: 2017-03-24 – 2017-03-27
  • Int'l Joint Research
• [Presentation] In situ肝灌流モデルによる殺鼠剤抵抗性野生クマネズミにおけるワルファリン代謝能の解明 (2016)
  • Author(s): 武田一貴、池中良徳、田中和之、中山翔太、谷川力、水川葉月、石塚真由美
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 2016-11-30 – 2016-12-02
• [Presentation] 化学物質の汚染環境に生きる野生動物の適応戦略 (2016)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 一般社団法人日本環境化学会25周年記念講演会
  • Place of Presentation: 発明会館地下ホール、東京都港区
  • Year and Date: 2016-11-16 – 2016-11-16
  • Invited
• [Presentation] Monitoring of blood lead levels (BLLs) in dogs and chickens from lead pollution area, Kabwe, Zambia. (2016)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
  • Organizer: International Doctoral Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Place of Presentation: Hokkaido University,Sapporo,Hokkaido, Japan
  • Year and Date: 2016-11-09 – 2016-11-11
  • Int'l Joint Research
• [Presentation] Characteristic for biotransformation of polychrolinated biphenyls in cats. (2016)
  • Author(s): Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kohki Takaguchi, Shinsuke Tanabe, Mayumi Ishizuka
  • Organizer: The 7th SETAC World Congress/37th SETAC North America Annual Meeting
  • Place of Presentation: Rosen Shingle Creek, Orlando, FL, USA
  • Year and Date: 2016-11-06 – 2016-11-10
  • Int'l Joint Research
• [Presentation] Contamination status of organohalogen compounds and their hydroxylated metabolites in pet cats and dogs: effects on thyroid hormones homeostasis. (2016)
  • Author(s): Kei Nomiyama, Yasuo Yamamoto, Hazuki Mizukawa, Mitsuyoshi Takiguchi, Akifumi Eguchi, Shouta M.M. Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Tatsuya. Kunisue, Shinsuke Tanabe.
  • Organizer: The 7th SETAC World Congress/37th SETAC North America Annual Meeting
  • Place of Presentation: Rosen Shingle Creek, Orlando, FL, USA
  • Year and Date: 2016-11-06 – 2016-11-10
  • Int'l Joint Research
• [Presentation] In vivo analysis of PCB metabolic capacities and effects on the thyroid hormone in cats. (2016)
  • Author(s): Hazuki, Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Hiroyuki Nishikawa, Kohki Takaguchi, Aksorn Saengtienchai, Tsend-ayush Sainnoxoi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe, Mayumi Ishizuka.
  • Organizer: The 9th International PCB Workshop
  • Place of Presentation: Kobe International Conference Center, Kobe, Japan
  • Year and Date: 2016-10-09 – 2016-10-13
  • Int'l Joint Research
• [Presentation] 野生げっ歯類の殺鼠剤の抵抗性メカニズムと非対象動物に対する毒性メカニズム (2016)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 日本哺乳類学会2016年度大会
  • Place of Presentation: 筑波大学、つくば市、茨城県
  • Year and Date: 2016-09-23 – 2016-09-26
  • Invited
• [Presentation] Investigation of Warfarin Metabolic Ability of Warfarin Resistant Roof Rats by in situ Liver Perfusion. (2016)
  • Author(s): Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 4th Sapporo Summer Seminar for One Health (SaSSOH)
  • Place of Presentation: Hokkaido University,Sapporo, Japan
  • Year and Date: 2016-09-20 – 2016-09-21
  • Int'l Joint Research
• [Presentation] Lead exposure on human samples in African countries and lead pollution in Kabwe, Zambia. (2016)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
  • Organizer: The 4th Sapporo Summer Seminar for One Health (SaSSOH)
  • Place of Presentation: Hokkaido University,Sapporo, Japan
  • Year and Date: 2016-09-20 – 2016-09-21
  • Int'l Joint Research
• [Presentation] A glycomics approach to renal biomarkers in birds. (2016)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama, Hazuki Mizukawa, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka, Keisuke Saito, Yukiko Watanabe, Mayumi Ishizuka
  • Organizer: The 4th Sapporo Summer Seminar for One Health (SaSSOH)
  • Place of Presentation: Hokkaido University,Sapporo, Japan
  • Year and Date: 2016-09-20 – 2016-09-21
  • Int'l Joint Research
• [Presentation] The effect of environmental pollutants to pet animals ~Level and effects of Persistent organic pollutants (POPs) to domestic cat~. (2016)
  • Author(s): Tsend-ayush Sainnokhoi, Hazuki Mizukawa, Misaki Maehara, Nozomu Yokoyama, Osamu Ichii, Mitsuyoshi Takiguchi, Kei Nomiyama, Aksorn Saengtienchai, Shinsuke Tanabe, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka.
  • Organizer: The 4th Sapporo Summer Seminar for One Health (SaSSOH)
  • Place of Presentation: Hokkaido University,Sapporo, Japan
  • Year and Date: 2016-09-20 – 2016-09-21
• [Presentation] 鳥類における新規腎障害マーカーの探索 (2016)
  • Author(s): 石井千尋、池中良徳、市居修、中山翔太、西村紳一郎、大橋哲、田中誠一、齊藤慶輔、渡邊有希子、水川葉月、石塚真由美
  • Organizer: 第22回日本野生動物医学会
  • Place of Presentation: 宮崎市民プラザ、宮崎市
  • Year and Date: 2016-09-16 – 2016-09-18
• [Presentation] 鳥類におけるグルクロン酸抱合酵素による薬物代謝 (2016)
  • Author(s): 新屋惣、池中良徳、中山翔太、石井千尋、水川葉月、齊藤慶輔、渡邉有希子、伊藤真輝、高江洲昇、坂本健太郎、石塚真由美
  • Organizer: 第22回日本野生動物医学会
  • Place of Presentation: 宮崎市民プラザ、宮崎市
  • Year and Date: 2016-09-16 – 2016-09-18
• [Presentation] UGT2Bサブファミリーに着目した食肉目におけるグルクロン酸抱合能の動物種差解明 (2016)
  • Author(s): 近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美
  • Organizer: 平成28年度内外環境応答・代謝酵素研究会
  • Place of Presentation: 静岡県立大学薬学部、静岡市、静岡県
  • Year and Date: 2016-09-16 – 2016-09-18
• [Presentation] 野生動物及び実験動物におけるグルクロン酸抱合酵素の動物種差解明 (2016)
  • Author(s): 近藤誉充、池中良徳、中山翔太、水川葉月、Aksorn Saengtienchai、Yared Beyene、坂本健太郎、和田昭彦、服部薫、三谷曜子、田辺信介、野見山桂、石塚真由美
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 日本大学生物資源科学部、藤沢市、神奈川県
  • Year and Date: 2016-09-06 – 2016-09-08
• [Presentation] 家畜・家禽の鉛安定同位体生体内分別の種差および歩哨動物としての有用性評価 (2016)
  • Author(s): 栂尾正雄、中山翔太、John Yabe、池中良徳、中田北斗、石井千尋、水川葉月、Yared B. Yohannes、 Aksorn Saengtienchai、石塚真由美
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 日本大学生物資源科学部、藤沢市、神奈川県
  • Year and Date: 2016-09-06 – 2016-09-08
• [Presentation] X線照射したヒト子宮頸がん由来HeLa細胞におけるミトコンドリア機能を中心としたエネルギー代謝応答の解析 (2016)
  • Author(s): 山本久美子、池中良徳、一瀬貴大、石塚真由美、安井博宣、鵜飼光子、山盛徹、 稲波修
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 日本大学生物資源科学部、藤沢市、神奈川県
  • Year and Date: 2016-09-06 – 2016-09-08
• [Presentation] ヒト子宮頚部がんHeLa細胞における放射線照射後のミトコンドリア応答 (2016)
  • Author(s): 稲波修、山本久美子、池中良徳、一瀬貴大、石塚真由美、安井博宣、鵜飼光子、山盛徹
  • Organizer: 第69回日本酸化ストレス学会学術年会
  • Place of Presentation: 仙台国際センター会議 棟、仙台市、宮城県
  • Year and Date: 2016-08-30 – 2016-08-31
• [Presentation] Kabwe childhood lead poisoning: past, present and future (2016)
  • Author(s): John Yabe, Shouta MM Nakayama, Yoshinori Ikenaka, Yared B. Yohannes, Haruya Toyomaki, Kennedy Choongo, Kaampwe Muzandu and Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] Lead exposure on human samples in African countries: a mini review (2016)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] Risk Assessment of Heavy Metals via Consumption of Muscle and Offal of Free-Range Animals from Benin City (2016)
  • Author(s): Emmanuel Temiotan Ogbomida, Shouta M.M. Nakayama, Nesta Bortey-Sam, Balazs Oroszlany, Isioma Tongo, Alex Ajeh Enuneku, Ogbeide Ozekeke, Martins Oshioriamhe Ainerua, Iriagbonse Priscillia Fasipe, Lawrence Ikechukwu Ezemonye, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] Creating a model of renal damage in chicken and glycomic approach to identify novel biomarkers for kidney injury in birds (2016)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka, Keisuke Saito, Yukiko Watanabe, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] Cytochrome P450 expression in the rabbit (2016)
  • Author(s): Walaa Fathy Saad Eldin, Wageh S. Darwish, Yoshinori Ikenaka, Shouta M. Nakayama, Hazuki Mizukawa and Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] Pb levels and isotope ratio profiles in kidneys of Japanese wild rats (2016)
  • Author(s): Shouta M.M. Nakayama, Hokuto Nakata, Balazs Oroszlany, Yoshinori Ikenaka, Hazuki Mizukawa, Kazuyuki Tanaka, Tsunehito Harunari, Tsutomu Tanikawa, Yared B. Yohannes, Aksorn Saengtienchai, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] Metabolic capacities of polychlorinated biphenyls (PCBs) in cats and dogs (2016)
  • Author(s): Hazuki Mizukawa, Kei Nomiyama, Shinsuke Tanabe, Misaki Maehara, Nozomu Yokoyama,Osamu Ichii, Mitsuyoshi Takiguchi, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] Is there species difference of biological variation of lead (Pb) isotopic composition between livestock and poultry? (2016)
  • Author(s): Masao Togao, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Yoshinori Ikenaka, Chihiro Ishii, Yared B. Yohannes, Hazuki Mizukawa, Wageh Sobhy Darwish, Aksorn Saengtienchai, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] Pharmacokinetic analysis of warfarin resistant roof rats (Rattus rattus) in Tokyo (2016)
  • Author(s): Kazuki Takeda, Yoshinori Ikenaka, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Giza, Egypt
  • Year and Date: 2016-08-29 – 2016-08-31
  • Int'l Joint Research / Invited
• [Presentation] N-glycans as potential novel biomarkers for kidney injury in avian species. (2016)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka, Osamu Ichii, Shouta M.M. Nakayama,Hazuki Mizukawa, Shin-Ichiro Nishimura, Tetsu Ohashi, Masakazu Tanaka,Keisuke Saito, Yukiko Watanabe, Mayumi Ishizuka.
  • Organizer: 65th International Conference of the Wildlife Disease Association,
  • Place of Presentation: Greek Peak Mountain Resort, Cortland, New York, USA
  • Year and Date: 2016-07-31 – 2016-08-05
  • Int'l Joint Research
• [Presentation] Human health risk due to polycyclic aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites. (2016)
  • Author(s): Nesta Bortey-Sam, Yoshinori Ikenaka, Shouta M.M. Nakayama, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka.
  • Organizer: 第30回北海道薬物作用談話会
  • Place of Presentation: 北海道大学、札幌市
  • Year and Date: 2016-07-31 – 2016-07-31
• [Presentation] ヒト子宮頸がんHeLa細 胞における放射線照射後のエネルギー生産とその意義 (2016)
  • Author(s): 稲波 修、山本久美子、西村英里、房 知輝、酒井友里、鈴木基史、池中良徳、一瀬貴大、石塚真由美、安井博宣、鵜飼光子、山田健一、山崎俊栄、山盛 徹
  • Organizer: 第54回日本放射線腫瘍学会生物部会学術大会
  • Place of Presentation: I-siteなんば、大阪市、大阪府
  • Year and Date: 2016-07-15 – 2016-07-16
• [Presentation] KAMPAI -Team 2, PAST, PRESENT and FUTURE- (2016)
  • Author(s): Shouta M.M. Nakayama, John Yabe, Yared Beyene, Haruya Toyomaki, Kaampwe Muzandu, Kennedy Choongo, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
  • Organizer: Kick-Off Symposium for the “The Project for Visualization of impact of chronic/latent chemical hazard and Geo-Ecological Remediation in Zambia”
  • Place of Presentation: CRESTA Golfview Hotel, Lusaka, Zambia
  • Year and Date: 2016-07-14 – 2016-07-14
  • Int'l Joint Research
• [Presentation] 脂肪組織における芳香族炭化水素受容体(AhR)の機能解明 (2016)
  • Author(s): 本平 航大、池中 良徳、ワギ ダルウィシュ、中山 翔太、水川 葉月、石塚 真由美
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋市
  • Year and Date: 2016-06-29 – 2016-07-01
• [Presentation] 東京由来ワルファリン抵抗性クマネズミクローズドコロニーでのワルファリン体内動態の解明 (2016)
  • Author(s): 武田一貴、池中良徳、田中和之、谷川力、中山翔太、水川葉月、石塚真由美
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋市
  • Year and Date: 2016-06-29 – 2016-07-01
• [Presentation] ハリネズミは化学物質高感受性種？ African hedgehog (Atalerix albiventris)で観察された低薬物代謝能 (2016)
  • Author(s): アクソルン サエンティエンチャイ、池中 良徳、ネスタ サム、ウスマ ジャムナーク、水川 葉月、中山 翔太、石塚 真由美
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋市
  • Year and Date: 2016-06-29 – 2016-07-01
• [Presentation] ポリ塩化ビフェニル（PCBs）のin vivo暴露によるネコの異物代謝解明と甲状腺ホルモンへの影響評価 (2016)
  • Author(s): 水川 葉月、前原 美咲、横山 望、市居 修、滝口 満喜、野見山 桂、西川 博之、池中 良徳、中山 翔太、高口 倖暉、田辺 信介、石塚 真由美
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋市
  • Year and Date: 2016-06-29 – 2016-07-01
• [Presentation] ヒト尿中ネオニコチノイドおよびその代謝産物の高感度分析による暴露実態の解明 (2016)
  • Author(s): 池中 良徳、石塚 真由美
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋市
  • Year and Date: 2016-06-29 – 2016-07-01
  • Invited
• [Presentation] UGTの動物種差 (2016)
  • Author(s): 石塚 真由美、中山 翔太、水川 葉月、池中 良徳
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋市
  • Year and Date: 2016-06-29 – 2016-07-01
  • Invited
• [Presentation] Human health risk due to polycyclic aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites. (2016)
  • Author(s): Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M.M. Nakayama, Kwadwo A. Asante, Christian Obirikorang, Elvis Baidoo, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka.
  • Organizer: SETAC Europe 26th Annual Meeting
  • Place of Presentation: La Cite Nantes Congress Center, Nantes, France
  • Year and Date: 2016-06-08 – 2016-06-10
  • Int'l Joint Research
• [Presentation] Plasma essential trace element concentrations in dogs with chronic enteropathy. (2016)
  • Author(s): Nozomu Yokoyama, Hiroshi Ohta, Hazuki Mizukawa, Yumiko Kagawa, Shouta Nakayama, Noboru Sasaki, Keitaro Morishita, Kensuke Nakamura, Yoshinori Ikenaka, Mayumi Ishizuka, Mitsuyoshi Takiguchi.
  • Organizer: American College of Veterinary Internal Medicine Forum 2016
  • Place of Presentation: Colorado convention center,Denver,Colorado, U.S.A
  • Year and Date: 2016-06-08 – 2016-06-10
  • Int'l Joint Research
• [Presentation] ネコにおけるポリ塩化ビフェニル（PCBs）の異物代謝機構解明と甲状腺ホルモンへの影響評価 (2016)
  • Author(s): 水川葉月、前原美咲、横山望、市居修、滝口満喜、野見山桂、西川博之、池中良徳、中山翔太、高口倖暉、田辺信介、石塚真由美
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 2016-06-08 – 2016-06-10
• [Presentation] ヒト尿中のネオニコチノイドおよびその代謝産物の分析法の確立とヒトへの曝露評価 (2016)
  • Author(s): 池中 良徳、藤岡 一俊、平 久美子、中山 翔太、水川 葉月、一瀬 貴大、Jemima Tiwaa Marfo、有薗 幸司、加藤 恵介、石坂 真澄、馬場 浩司、川上 智規、石塚 真由美
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 2016-06-08 – 2016-06-10
• [Presentation] 有機ハロゲン化合物によるコンパニオンアニマルの汚染実態と甲状腺ホルモンへの影響評価 (2016)
  • Author(s): 野見山 桂、山本 恭央、水川 葉月、江口 哲史、滝口 満喜、中山 翔太、池中 良徳、石塚 真由美、国末 達也、田辺 信介
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 2016-06-08 – 2016-06-10
• [Presentation] メタボローム解析を用いたPCBsによるイエネコの毒性影響評価 (2016)
  • Author(s): 西川博之、野見山桂、水川葉月、横山望、市居修、滝口満喜、石塚真由美、池中良徳、中山翔太、江口哲史、国末達也、田辺信介
  • Organizer: 第25回環境化学討論会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 2016-06-08 – 2016-06-10
• [Remarks] 北海道大学大学院獣医学研究院 毒性学教室 ホームページ
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Remarks] ケミカルハザード問題の克服に向けた国際コミッション
  • URL: http://aa.vetmed.hokudai.ac.jp/
• [Funded Workshop] 8th International Toxicology Symposium in Africa (2016)
  • Place of Presentation: Ｇiza, Egypt
  • Year and Date: 2016-08-28 – 2016-08-31