2016 Fiscal Year Final Research Report
Exploration of novel drug materials from natural products of Himalayan area
| Project/Area Number |
26305006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Natural medicines
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
Itoh Susumu 昭和薬科大学, 薬学部, 教授 (70223154)
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| Co-Investigator(Kenkyū-buntansha) |
高野 昭人 昭和薬科大学, 薬学部, 教授 (00255910)
中根 孝久 昭和薬科大学, 薬学部, 准教授 (80384634)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | TGF-β / YAP / シダ / ネパール / トリテルペノイド / Swertia属植物 / リンドウ科 / 薬用植物 |
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| Outline of Final Research Achievements |
We collected several plants derived from Pteridophyta, Swertia, Gentiana, Ephedra and Taraxacum which grow in Ilam, Daman and Muktinath in Nepal. Then, we purified a number of sesterterpenes and oxidaized triterpenoids from these plants to succeed dermination of thier chemical structres. Besides, we tried to test cultivation of medial plants originally grown in Nepal and plants which Chinese medicines are made of in Nepal.
Among triterpenoids which have been puried, we could find that the acetain triterpenoid can specifically interact with YAP and TAZ, whereas none of compounds affected TGF-beta and YAP signals.
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| Free Research Field |
分子細胞生物学
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