A comparative study of intrinsic factor activating inflammasome between Turkey and Japan

2016 Fiscal Year Final Research Report

• Project/Area Number: 26305024
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Hygiene and public health
• Research Institution: Ehime University
• Principal Investigator: Masumoto Junya 愛媛大学, プロテオサイエンスセンター, 教授 (20334914)
• Co-Investigator(Kenkyū-buntansha): Coban Cevayir 大阪大学, 免疫学フロンティアセンター, 教授 (00397712) ; 石井 健 国立研究開発法人医薬基盤・健康・栄養研究所, 創薬基盤研究部, プロジェクトリーダー (00448086) ; 伊藤 有紀 愛媛大学, プロテオサイエンスセンター, 助教 (10608334) ; 澤崎 達也 愛媛大学, プロテオサイエンスセンター, 教授 (50314969) ; 上松 一永 信州大学, 医学部, 准教授 (60262721) ; 右田 清志 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 病因解析研究部長 (60264214) ; 大澤 春彦 愛媛大学, 医学(系)研究科(研究院), 教授 (90294800)
• Research Collaborator: Ozoren Nesrin Bogazici University, Professor ; Kaneko Naoe 愛媛大学, 大学院医学系研究科, 技術員
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: インフラマソーム / トルコ / 家族性地中海熱 / 環境因子

Outline of Final Research Achievements

Autoinflammatory disease is refractory inflammatory diseases characterized by recurrence of periodic fever. In an autoinflammatory disease, familial Mediterranean fever, environmental factors are considered to be important as well as genetic factors, because there are some differences among Turkish and Japanese cases despite having the same genetic mutation. Therefore, in this study, we focused on environmental factors in Turkey and Japan, and analyzed environmental factors that cause periodic fever in a cell-free inflammasome reconstitution system. We have identified several candidates of environmental factors. These results were discussed with Professor of Bogazici University at Protein Island Matsuyama International Symposium in 2016.

Free Research Field

病理学