2016 Fiscal Year Final Research Report
Molecular dynamic simulation for evaluation of an impact of mutations in a genetic disease
| Project/Area Number |
26330331
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Life / Health / Medical informatics
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 分子動力学 / 構造生物学 / 分子遺伝学 |
|---|
| Outline of Final Research Achievements |
Rapid progress in structural biology and molecular genetics is obvious, yet their cooperation remains out of reach. Our aim is to develop in silico pipeline, which enables us to assess the impact of the mutations found by domestic and international genetics laboratories from the structural viewpoint. Specifically, we analyzed the mutations not only by static structural analysis such as homology modeling and free energy change calculation but also by dynamic analysis using molecular dynamics (MD) simulation. We showed that MD is a powerful tool to evaluate effects of gene mutations on protein structure and function.
|
| Free Research Field |
生化学、構造生物学
|
