Predicting changes in aquatic toxicity of chemicals resulting from solvent or dispersant use as vehicle

2016 Fiscal Year Final Research Report

• Project/Area Number: 26340087
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental risk control and evaluation
• Research Institution: Kanagawa Institute of Technology
• Principal Investigator: Kikuchi Mikio 神奈川工科大学, 応用バイオ科学部, 名誉教授 (70308534)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 生態毒性 / 毒性 / 化学物質 / ミジンコ類 / 魚類 / 吸着 / 濃縮性

Outline of Final Research Achievements

In aquatic toxicity testing of poorly water-soluble substances, it can be difficult to prepare a concentrated stock solution and maintain a constant exposure concentration in the water. These cases typically involve preparation of the concentrated stock solution in a water-miscible organic solvent or a surface-active dispersant as a vehicle. It is necessary to select an appropriate type and concentration of vehicle prior to toxicity testing, as a substance's toxicity measured using a vehicle can differ from that of the substance alone. The purposes of this study is to develop a methodology for predicting the influence of vehicle on toxicity of test substances.
The adsorption changes on silicone film of a test substance by using vehicle was closely correlated with the changes in toxicity. The adsorption test and physicochemical properties of a substance can predict toxicity changes of the substance by using vehicle. The usefulness of our method was inspected by the published data.

Free Research Field

生態毒性学