Effects of fatty acids on the obese patients suffered from inflammatory bowel disease and development of examination of feces

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Yamaguchi University
• Principal Investigator: TOKUDA Nobuko 山口大学, 医学(系)研究科(研究院), 教授 (70227578)
• Research Collaborator: TSUNEOKA Hidehiro 山口大学, 大学院医学系研究科, 教授 (40437629)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脂肪酸 / 炎症 / 肥満 / リンパ節 / FABP

Outline of Final Research Achievements

Fibroblastic reticular cells (FRCs) produce collagen-rich reticular fibers in immune organs. We have shown FRCs express fatty acid binding protein 7 (FABP7), a chaperon which has a high affinity to n-3 polyunsaturated fatty acids. Similar fibroblasts were seen in inflamed intestine. Mice were infected on the skin of the flank with simplex virus type 1 (HSV-1) and the responses in the primary draining brachial LN (bLN) were analyzed. After HSV infection, expansion and proliferation of bLN FRCs increased and Fabp7 genes were highly upregulated in FRCs. Expression of FABP7 mRNA in FRCs after HSV infection were significantly upregulated. However, any deficiency was not defined and expansion of FRCs was unaffected compared with wild-type mice. In diet-induced fat mice, FABP7 might affect the increasing fibroblasts. FABP7 and some chaperons may be involved in fibroblast homeostasis, possibly by modulating lipid metabolism in fibroblasts at the inflammation including high fat state.

Free Research Field

医学（免疫学・解剖学・栄養学）