Glutamine, dietary fiber, oligosaccharide and Bifidobacterium lungum exert symbiotic effects on adjuvant arthritis in rats.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350157
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Nara Medical University
• Principal Investigator: KUBO KAORU 奈良県立医科大学, 医学部, 准教授 (20254493)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 関節リウマチ / 喫煙 / シンバイオテイクス

Outline of Final Research Achievements

An immunologically caused paw swelling and the decrease of bone density in the adjuvant arthritis were significantly inhibited by taking the diet including 2% glutamine, 3.2% polydextrose, 3% lactulose and 5% Bifidobacterium lungum for 8 weeks. This diet intake improved a reduced Firmicutes to Bacteroidetes ratio in cecal content. Cigarette smoking exposure for 8 weeks increased an immunologically caused paw swelling. The diet including 2% glutamine, 1.6% polydextrose, 0.48% lactulose and 5% Bifidobacterium lungum significantly inhibited this increased paw swelling. The above-mentioned result suggested improvement of the rheumatoid arthritis by symbiotic effects of glutamine, polydextrose, lactulose and Bifidobacterium lungum via improving an intestinal dysbiosis.

Free Research Field

実験動物学　薬理学