Personalized Biomarker Analysis Using Circulating Tumor Cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350557
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Toyama Industrial Technology Center,
• Principal Investigator: TAKATA Koji 富山県工業技術センター, 機械電子研究所, 主任研究員 (40530621)
• Co-Investigator(Renkei-kenkyūsha): OHNAGA Takashi 富山県工業技術センター, 中央研究所, 副主幹研究員 (10416133) ; OBATA Tsutomu 富山県工業技術センター, 中央研究所, 副主幹研究員 (30416143)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 循環腫瘍細胞 / 癌 / マイクロ流路チップ

Outline of Final Research Achievements

Circulating tumor cells (CTC) are tumor-derived cells circulating in bloodstream and could be seeds for metastases. Easy-to-use isolation and analysis methods of CTC could be applicable to cancer diagnosis and personalized medicine. In this study, we developed microfluidic chips which could be used for size-based cell separation. We showed that the chip could successfully separate cell line spiked to blood, and showed that CTC isolated from clinical sample by the chip could be used for RT-PCR-based biomarker analysis.

Free Research Field

マイクロ流路チップの医療応用