2016 Fiscal Year Final Research Report
A Common Genetic Variant of the Chromogranin A-derived peptide Catestatin is Associated with Atherogenesis and Hypertension in a Japanese Population
| Project/Area Number |
26350881
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | カテスタチン |
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| Outline of Final Research Achievements |
CHGA gives rise to cardiovascular/metabolic regulatory peptides, such as catestatin (CST).While CST is a potent inhibitor of catecholamine secretion. Recently, several SNPs were identified in the CST domains of CHGA locus in different populations. Among the discovered SNPs, CST variant allele Ser-364 was associated with blood pressure alteration. In this study, we examined whether this CST variant alleles exist and influence cardiovascular and metabolic phenotypes in Japanese population. In 343 participants, the minor allele frequency of CST variant Ser-364 was 6.10%. The presence of Ser-364 allele was associated with increased in baPWV (an index of systemic arterial stiffness), suggesting an initiation and/or progression atherogenesis and hypertension. The Ser-364 allele was also associated with elevated systolic blood pressure and pulse pressure, consistent with increased baPWV.
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| Free Research Field |
内分泌
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