Elucidation of the mechanisms by which neurogenesis is impaired in dyslipidemic patients

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: National Defense Medical College
• Principal Investigator: Ishizuka Toshiaki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 教授 (30399117)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 神経前駆細胞 / 神経分化 / 酸化LDL / LOX-1 / PKC / Ａｋｔリン酸化 / CREBリン酸化

Outline of Final Research Achievements

We revealed that stimulation with oxidized LDL (ox-LDL) significantly suppressed the differentiation of mouse neural progenitor cells into neural cells. In addition, it was found that the effects of ox-LDL is due to the activation of LOX-1 which activates PKC and inhibits the phosphorylation of Akt and CREB. Thus, the modulation of LOX-1 may ameliorate the impaired neurogenesis and neuropsychiatric function in dyslipidemic patients.

Free Research Field

総合領域