Assembling Methods of Functional Molecules for Development of Muti-modarity Molecular Probes

2016 Fiscal Year Final Research Report

• Project/Area Number: 26350971
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Yoshida Suguru 東京医科歯科大学, 生体材料工学研究所, 准教授 (10583750)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ケミカルバイオロジー / 有機化学 / 分子プローブ / アジド / クリック反応

Outline of Final Research Achievements

"Molecular probe" which is a multifunctional molecule for advancing life science research has attracted attention as an important tool. However, synthesis of multifunctional molecules such as multi-modality probes is not easy. We studied on multi-click chemistry to enable facile preparation of a variety of multi-functional molecules by sequential use of click reactions, which are widely used as a reliable method to conjugate two molecules. As the results, we successfully developed a method to transiently protect the clickability of cyclic alkyne moieties toward azides. This method enabled the synthesis of cyclic alkynes bearing a functional group from functional azides via a terminal alkyne-selective click reaction.

Free Research Field

ケミカルバイオロジー、有機合成化学