2016 Fiscal Year Final Research Report
Functional analysis of the role of hippocampal CA2 region in social behaviour and memory.
| Project/Area Number |
26350979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Niigata University |
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Principal Investigator |
Abe Manabu 新潟大学, 脳研究所, 准教授 (10334674)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 海馬 / 記憶 / 遺伝子改変マウス |
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| Outline of Final Research Achievements |
The aim of this study was to examine the role of CA2 neurons in memory and social behavior. The function of the hippocampal CA2 region remains largely unknown. To control neural activity by using CA2 neuron-selective gene-targeting system, we made several knock-in lines, in which Cre recombinase or tetracycline transactivator was inserted into the translational initiation site of the targeted genes (Rgs14, Amigo2, Abat and so on) in frame. Additionally, we made a new line expressing tdTomato reporter under control of Cre recombinase. The mutant lines developed in this study could be useful tools for analysis of higher brain functions.
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| Free Research Field |
分子神経生物学
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