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2017 Fiscal Year Final Research Report

The role of neuronal diversity in the neural circuit of somatosensory cortex

Research Project

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Project/Area Number 26350980
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionOsaka University

Principal Investigator

HIRAYAMA Teruyoshi  大阪大学, 生命機能研究科, 特任講師(常勤) (40437398)

Project Period (FY) 2014-04-01 – 2018-03-31
Keywords神経細胞 / 多様性 / 神経回路形成
Outline of Final Research Achievements

Using several c-Pcdh deletion mutant and conditional knockout(cKO) mouse lines, I investigated the role of c-Pcdh in the somatosensory cortical barrel formation. Pcdh-alpha, Pcdh-beta and Pcdh-alpha-beta deletion mutant mice showed normal barrel formation. Pcdh-gamma deletion mutant mice died within 24h after birth. I analyzed Pcdh-gamma cKO mice and found that obscure barrel formation. Based on these results, I generated c-Pcdh gene modified mouse using CRISPR/Cas9 system.

Free Research Field

神経科学 ゲノム科学

URL: 

Published: 2019-03-29  

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