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2016 Fiscal Year Final Research Report

Molecular mechanism of micelle binding and fusion process to lipid membranes

Research Project

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Project/Area Number 26410012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical chemistry
Research InstitutionNagoya University

Principal Investigator

Yoshii Noriyuki  名古屋大学, 工学研究科, 特任准教授 (70371599)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords分子動力学計算 / ミセル / 脂質膜
Outline of Final Research Achievements

In this study, free energy analysis based on molecular dynamics simulation was carried out for the binding/fusion process of two spherical micelles and the binding/fusion process of the spherical micelle to the lipid membrane surface. As a target system, SDS micelle, which is a representative spherical micelle, and a planar membrane patch of a lipid bilayer membrane composed of POPC as a model of a real cell membrane were used. Molecular level mechanism of fusion process due to thermal fluctuation was elucidated, and time constants required for micelle binding and fusion were evaluated.

Free Research Field

物理化学

URL: 

Published: 2018-03-22  

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