Synthesis of Glucosamine Introduced Platinum and Palladium Complexes and Their Anti-Cancer Activities Based on Heteroatom Chemistry

2016 Fiscal Year Final Research Report

• Project/Area Number: 26410056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Organic chemistry
• Research Institution: Osaka Prefecture University
• Principal Investigator: Nomoto Akihiro 大阪府立大学, 工学(系)研究科(研究院), 准教授 (60405347)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 有機元素化学 / 抗がん剤 / 錯体化学 / 有機合成化学

Outline of Final Research Achievements

We focused on the conjugation of sugar to improve metal complexes as anti cancer drugs. Cancer cells have a higher affinity for glucose than regular healthy cells, thus incorporation of glucose moiety to metal complex may produce the efficient anticancer reagent uptaken into cancer cells. Taking advantage of this property, required amount of chemotherapeutic reagents can be reduced.
Glucosamine-conjugated palladium and platinum complexes have been synthesized and anti-cancer properties were investigated. To prevent elimination of metal, quinolinol ligand was used to afford complexes. From the results of X-ray analysis, each molecular structure is almost same between Pt and Pd complexes. However, the anticancer activities were quite different.

Free Research Field

有機典型元素化学