2016 Fiscal Year Final Research Report
Elucidation of ligand-receptor signaling that regulates the corticospinal tract collateralization
| Project/Area Number |
26430017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 神経科学 / 解剖学 / 発生・分化 / 神経回路 / 軸索側枝 |
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| Outline of Final Research Achievements |
Corticospinal tract, which is the major subcortical output from the neocortex, extends the axon collaterals from the main shaft to several nuclei, enabling coordination of neural activity. In order to clarify the molecular mechanism controlling the formation of axon collaterals, we screened and analyzed candidate receptors and their ligands which are involved in axon collateral formation. We found that one of the candidate receptors (receptor #13) and its ligand were complementarily expressed in the cortex and the pontine nucleus, and their expression pattern determined the projection area of the axon collateral branches. Furthermore, receptor #13 was also involved in collateral branch formation that plays a compensatory mechanism during brain injury. These results are of great significance to elucidate the common molecular basis that underlies axon collateralization and to subsequently apply in recovery of neural function.
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| Free Research Field |
神経科学
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