2016 Fiscal Year Final Research Report
Roles of cannabinoid-dependent plasticity in the developing neuronal circuit in the mouse barrel cortex
| Project/Area Number |
26430022
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology / General neuroscience
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
Chiaki Itami 埼玉医科大学, 医学部, 講師 (90392430)
|
|---|
| Research Collaborator |
LU Hui-chen インディアナ大学, 教授
HUANG J-Y インディアナ大学, 研究員
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 体性感覚野 / スパイクタイミング可塑性8(STDP) / カンナビノイド |
|---|
| Outline of Final Research Achievements |
Activation of cannabinoid CB1 receptors (CB1Rs) causes both physiological and morphological effects on the development of neuronal circuits. In the rodent barrel cortex, CB1R is required for the long-term depression (LTD) component of spike timing-dependent plasticity (STDP). We showed that CB1R activation caused LTD in a spike timing-dependent manner (t-LTD) at thalamocortical terminals. Since CB1R knockout (KO) mice showed disrupted thalamocortical projection, we concluded that endogenous CB1R signalling is important in translating physiological changes into morphological consequences.
|
| Free Research Field |
神経科学
|
