2016 Fiscal Year Final Research Report
Biological characteristics and maintenance of stemness in malignant glioma based on lipid metabolism
| Project/Area Number |
26430056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IWAKI Toru 九州大学, 大学院・医学研究院, 教授 (40221098)
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| Research Collaborator |
KITAGAWA Reika 九州大学, 大学院・医学系学府
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | グリオーマ / 腫瘍幹細胞 / 代謝 / エピジェネティクス |
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| Outline of Final Research Achievements |
Malignant gliomas are brain tumors resistant to multimodal therapy, representing the most malignant class of tumor in human. In the present study, we investigated metabolic state of malignant glioma cells to understand biological nature of the tumor and gain a clue to novel therapeutic approach. We found that both synthesis and utilization of lipids are increased in the tumor cells to contribute to the malignant nature. When we applied metoformin, a drug regulating metabolism, to the glioma cells, drastic changes were observed not only in metabolic state but also in the chemical modification of gene expression (epigenetics). These results indicate that the biological characteristics of malignant gliomas are dependent of crosstalk between metabolism and epigenetics.
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| Free Research Field |
神経病理学
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