Neuropathlogic analysis of axon and tau protein of human prion diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430060
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Saitama Medical University
• Principal Investigator: Masaki Takao 埼玉医科大学, 医学部, 教授 (50245487)
• Research Collaborator: NAKANO Yuta ; Bernardino Ghetti
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: プリオン / 軸索輸送 / クロイツフェルト・ヤコブ病 / アミロイド / タウ / 神経変性疾患

Outline of Final Research Achievements

In order to understand the propagation of prion protein of human prion diseases, we neuropathologically analyzed human brain tissue using anti-prion immunohistochemistry. Although axonal immunoreactivity (ir) was reported in the individuals with specific Gerstmann-Straussler-Scheinker disease (GSS) cases, there was no clear axonal anti-PrP-ir in sporadic and genetic Creutzfeldt-Jakob disease (CJD) as well as GSS. In contrast, anti-PrP-ir was observed along the neuronal cell soma, dendrites and axons in the hippocampus and temporal cortex in most of analyzed cases. Perineuronal PrP-ir was considered as characteristic findings in VV2 prion disease. Since there were no VV2 cases in the present study, we need more analysis the meaning of the findings.

Free Research Field

神経内科学