Functional analyses of TCTP in neural stem/progenitor cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430074
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Keio University
• Principal Investigator: Ohta Shigeki 慶應義塾大学, 医学部(信濃町), 講師 (20365406)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 神経幹細胞 / グリオーマ幹細胞 / TCTP1

Outline of Final Research Achievements

MIF (Macrophage migration inhibitory factor) was identified as a functional molecule, which supports the proliferation of murine neural stem/progenitor cells (NSPCs). We also identified a new factor TCTP1 (Tumor Protein Translationally-Controlled 1), contributing to the cell proliferation of mouse NSPCs. TCTP1 gene expression was regulated by MIF and TCTP1 gene silencing defected neurogenesis in human ES cell-derived neural stem cells (hES-NSCs). We also found that MIF-TCTP1-miR338-SMO signaling cascade regulated the cell proliferation in hES-NSCs. In addition, TCTP1 supported the glioma-initiating cell proliferation regulated by MIF.

Free Research Field

神経発生学