2017 Fiscal Year Final Research Report
Functional analysis of long non-coding using a mouse model
| Project/Area Number |
26430087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOBAYASHI Shin 東京医科歯科大学, 難治疾患研究所, 非常勤講師 (10397664)
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| Co-Investigator(Kenkyū-buntansha) |
幸田 尚 東京医科歯科大学, 難治疾患研究所, 准教授 (60211893)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | エピジェネティクス |
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| Outline of Final Research Achievements |
Long non-coding RNAs（lncRNA）are thought to be involved in various biological processes, but their functions in vivo largely remain to be elucidated. Here, we showed that targeted deletion of Fat60 lncRNA causes abnormal development, which resembles a human disease. Our results indicate that a functional loss of lncRNA abolishes proper development, suggesting that lncRNA could be a cause for human genetic disease.
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| Free Research Field |
実験動物学
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