Development of antibody-inducing vaccine models by analysis of B404 which neutralizes various SIV strains

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430091
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Kumamoto University
• Principal Investigator: Kuwata Takeo 熊本大学, エイズ学研究センター, 助教 (70346063)
• Co-Investigator(Renkei-kenkyūsha): MATSUSHITA Shuzo 熊本大学, エイズ学研究センター, 教授 (00199788) ; IGARASHI Tatsuhiko 京都大学, ウイルス研究所, 教授 (90467431)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: antibody / SIV / vaccine / HIV

Outline of Final Research Achievements

SIV-infected macaques, which is an animal model of HIV infection, was used for analysis to develop antibody-inducing vaccines. Binding of potent anti-SIV neutralizing antibody B404 was not affected by point mutations on Env, and was suggested to require the structure of antigen-binding domain with negative charges. The biased induction of B404-class antibodies in macaques suggested the effect of host factors in antibody induction. Moreover, maturation of antibodies resulted in increase of neutralization activity against homologous virus, but did not associated with cross-neutralization activity against heterologous viruses

Free Research Field

Virology