Drinking behavior modulation significantly prevent cardiac remodeling and improve survival in chronic heart failure rats

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Zheng Can 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (50443495)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Chronic heart failure / Drinking behavior / Thirst / Fluid restriction / Survival

Outline of Final Research Achievements

Given the lack of knowledge about fluid intake regulation and its consequences in patients with chronic heart failure (CHF), current guidelines do not provide clear direction for fluid management. This study aim to investigate altering drinking behaviors and explored fluid management strategies in a rat model of CHF.　We observed that the spontaneous per drinking volume (PDV) was significantly increased in rats with myocardial infarction (MI). There was a significant inverse correlation between the PDV at the second-week post-MI and the post-MI lifespan. Modulating the drinking behavior of rats with MI to involve frequent drinking of small PDVs significantly prevented cardiac remodeling, with a significant improved prognosis. These results suggest that increment of PDV may be a prognostic vicious factor after MI, and increasing the drinking frequency, with small PDVs, may be beneficial for preventing progression of cardiac dysfunction in CHF.

Free Research Field

医歯薬学