Analyses of molecular mechanism of the glycan-dependent adaptation of tumor cells to tumor microenvironments

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Kumamoto University
• Principal Investigator: Ohtsubo Kazuaki 熊本大学, 大学院生命科学研究部(保), 教授 (30525457)
• Co-Investigator(Renkei-kenkyūsha): KOREKANE Hiroaki 独立行政法人理化学研究所, 疾患糖鎖研究チーム, 研究員 (50421912) ; NAKAJIMA Kazuki 独立行政法人理化学研究所, 新液播く機能研究チーム, 研究員 (10442998)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 糖鎖修飾 / がん糖鎖 / シアリルTn抗原 / 転移 / 浸潤 / 低酸素

Outline of Final Research Achievements

We analyzed molecular mechanisms of the Sialyl-Tn (sTn) antigen-induced alterations encompassing the reduced cell proliferation, the acquisition of anti-oxidative stress and anti-apoptosis under hypoxic conditions which are based on the tumor adaptation to dramatically changing microenvironments, and then we found that sTn antigen reduces cell cycle and induces antioxidant enzymes that confers anti-apoptotic functions on tumor cells under hypoxic conditions. These sTn antigen-induced cellular functions are important for survival and metastasis of tumor cells.

Free Research Field

糖鎖生物学