2016 Fiscal Year Final Research Report
Elucidation of the gene variation accumulation mechanism in the tumor developmental process using HTLV -1 humanized mouse
| Project/Area Number |
26430126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Research Collaborator |
Yao Jinchun
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | HTLV-1 / ヒト化マウス / Tax / APOBEC |
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| Outline of Final Research Achievements |
An ATL-like condition of a patient onset process had been already accepted with the HTLV-1 infection humanized mouse and was intended that I clarified the instruction mechanism of the APOBEC3B gene that an expression instruction was confirmed in that.
As for the expression instruction of APOBEC3B, the participation of the virus product except Tax was thought about regardless of onset of Tax at the continuation infection in the neoplasia process whereas a rise in expression of APOBEC3B was observed with Tax expression at the initial infection to a humanized mouse. In addition, because APOBEC3B expression was controlled than a comparison between HAM patient specimen and physically unimpaired person result, an expression instruction of APOBEC3B was recognized by the instructions such as anti-HTLV-1 infection replies, and it was suggested that the variation of the host gene was accumulated.
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| Free Research Field |
腫瘍ウイルス学
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