2016 Fiscal Year Final Research Report
Establishment of the photodiagnosis for cancer using small molecule metabolism elucidation in cancer cells
| Project/Area Number |
26430141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 光線力学診断 / アミノレブリン酸 / ポルフィリン / 鉄代謝 / 薬物排出トランスポーター / 低酸素 / 休眠癌細胞 / 癌幹細胞 |
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| Outline of Final Research Achievements |
It is well known that porphyrin accumulates in cancer by the administration of aminolevulinic acid (ALA) to cancer patient and cancer diagnosis using this phenomenon is widely used. In this study, the mechanism of porphyrin accumulation is investigated. As a results, various kinds of transporters after ALA administration was important to porphyrin accumulation. Furthermore, we established the diagnostic method in cancer of difficulty treatment characteristics including hypoxic cancer or dormant cancer.
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| Free Research Field |
分子生物学
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