A novel pathway regulating memory T cell development for cancer immunotherapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430162
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Osaka University
• Principal Investigator: Fujiki Fumihiro 大阪大学, 医学系研究科, 特任助教(常勤) (40456926)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: メモリーT細胞

Outline of Final Research Achievements

Efficient memory T cell induction has been demanded for the development of a potent cancer immunotherapy. However, it remains unclear how memory T cell is induced. We previously identified a novel nutrient metabolism regulating the differentiation of memory T cell. Here, we show that new inhibitors against the metabolism process can enhance the efficacy of T cell-based cancer immunotherapy. Furthermore, we also demonstrate a novel mechanism regulating the expression of L-Selectin (CD62L), an important functional marker for memory T cells, in T cells. Thus, these results should provide us with a methodology for controlling T cell differentiation and contribute to develop more effective cancer immunotherapy.

Free Research Field

腫瘍免疫学、免疫学