2016 Fiscal Year Final Research Report
The identification of intact PI3P phosphatase and physiological role
| Project/Area Number |
26440020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Akita University |
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Principal Investigator |
EGUCHI SATOSHI 秋田大学, 医学(系)研究科(研究院), 助教 (70457117)
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| Co-Investigator(Renkei-kenkyūsha) |
Sasaki Takehiko 秋田大学, 医学系研究科, 教授 (50333365)
Horie Yasuo 秋田大学, 医学系研究科, 講師 (30282164)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | イノシトールリン脂質 / 脱リン酸化酵素 |
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| Outline of Final Research Achievements |
Phosphoinositide generated by various phosphoinositide kinase and phosphatase have different physiological functions. PI3P and PI(3,5)P2 is important for nutrient signaling and vesicular trafficking, however, its physiological function remains unclear. Therefore, I generated knockout mice of MTMRs which dephosphorylates PI3P and PI(3,5)P2 in vitro. Analysis of these knockout mice revealed that deficiency of MTMRs caused lung cancer and cardiac hypertrophy.
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| Free Research Field |
生化学
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