2016 Fiscal Year Final Research Report
The role of phospholipid metabolism in skin diseases
Project/Area Number |
26440036
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Structural biochemistry
|
Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
|
Research Collaborator |
NAKANISHI Hiroki
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 皮膚 / ケラチノサイト / ホスホリパーゼ / イノシトールリン脂質 |
Outline of Final Research Achievements |
We observed the change in the amount of PI(3,4,5)P3 and the activity of PI(3,4,5)P3 downstream signals in the epidermis of mice with psoriasis-like dermatitis. We also found signaling molecules involved in skin inflammation in phospholipase C(PLC) delta1 knockout mice. Our results contribute to understanding of the roles of PI(3,4,5)P3 and PLC delta1 downstream signals in psoriasis-like dermatitis.
|
Free Research Field |
脂質生化学
|