2016 Fiscal Year Final Research Report
Analysis of oncogenic signals regulated by novel type of Ras family protein
| Project/Area Number |
26440062
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
Tago Kenji 自治医科大学, 医学部, 講師 (20306111)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | Rasファミリー / 低分子量G蛋白質 / 発がんシグナル |
|---|
| Outline of Final Research Achievements |
It is well established that genetic mutations of Ras genes are involved in many cases of tumorigenesis. In this study, we found that a member of Ras family, kappaB-Ras contributes to the cellular transformation mediated the activation of protein kinase mTORC1. Furthermore, we purified the protein complexes including kappaB-Ras, and found that TRB3 which is identified as an interacting protein of kappaB-Ras functions as novel type of tumor suppressor. Although detailed mechanism is still unclear, it is clarified that TRB3 suppresses the oncogenic signals mediated the SUMO-conjugation of kappaB-Ras.
|
| Free Research Field |
細胞内情報伝達
|
