2016 Fiscal Year Final Research Report
The role of septin participating in the remodeling of neuronal circuits
| Project/Area Number |
26440095
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 細胞骨格 |
|---|
| Outline of Final Research Achievements |
Cytoskeletal remodeling in response to synaptic inputs is a critical process underlying structural plasticity, as is exemplified by the dependence of late-phase LTP and long-term memory on actin remodeling. Unbiased behavioral screening of several mouse lines that are deficient in or overloaded with a septin subunit or a related protein revealed that mice of one such line consistently underperform spatial learning tasks. The unique line may provide a clue to unknown molecular mechanism of spatial cognition and learning. Proteomic analysis revealed quantitative changes in the glutamate receptor subunits and other proteins in the hippocampus.
|
| Free Research Field |
分子神経科学
|
