2016 Fiscal Year Final Research Report
PINK1-mediated regulation of mitochondrial morphology and functions
| Project/Area Number |
26440106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Rikkyo University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ミトコンドリア / PINK1 / Parkin |
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| Outline of Final Research Achievements |
Mitochondria mainly contributes to cellular ATP production, and their morphology dynamically changes, i.e. they continuously divide and fuse each other. How mitochondrial morphology relates to their functions is watched with interest. Using nematode and mammalian cell lines, we indicated that PINK1, a key factor for mitochondrial quality control, controls mitochondrial morphology in nematode and demonstrated that PINK1activation induces necrosis-like cell death in mammalian cell lines. In particular, it is of interest in the relationship between PINK1-mediated cell death and loss of dopaminergic neurons in patients with Parkinson's disease.
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| Free Research Field |
分子細胞生物学
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